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siden 23. des.1998 (since Dec.23. 1998)
Sist oppdatert 5/3/2004

| Fordi den nevrologiske forskningen på ALS ofte har
interesse også for slag, og jeg derfor har hatt interessant kontakt med
med noen som er rammet av ALS, laget jeg i sin tid denne ALS-siden, men
har dessverre ikke hatt tid til å følge opp ALS-forskningen spesielt.
Så, om det finnes noen, som ønsker å hjelpe til med å redigere denne
siden, ville jeg være takknemlig!
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Skandinaviske ALS-kontaktsider på
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Can
transplanted stem cells restore function and increase survival?
Dr. Ole Isacson, Director of the Neuroregeneration Laboratories and
Morris K. Udall Parkinson's Disease Research Center of Excellence at the
McLean Hospital, will apply his expertise in transplant studies in
Parkinson's disease to investigate whether stem cell transplants into a rat
model of ALS will restore function and increase survival. Genetically
modified embryonic stem cells (HB9 GFP ES cells) will be provided by Dr. Tom
Jessell. (This work has recently been published in the journal Cell.)
Research in Dr. Tom Jessell's laboratory has demonstrated that these mouse
embryonic stem cells can be differentiated into motor neurons (the
population of nerve cells that die in ALS)
Can
human motor neurons be generated from stem cells?
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Doctor's Guide om ALS
(Lou Gehrig's Disease)
The latest medical news and information for patients or friends/parents of
patients diagnosed with ALS
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The ALS Association
The ALS Association seeks to promote awareness and understanding of ALS and
the work of The ALS Association by providing up-to-date information and
education materials to the ALS community... ALS patients and families,
caregivers, researchers and members in the health care fields. ALS
(amyotrophic lateral sclerosis) is a fatal neurodegenerative disease. It is
often called Lou Gehrig's disease.
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Harvard
Neurology Web ALS Forum
This is a webforum to discuss and comment on ALS
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Foreningen
for Muskelsyke (FFO)
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FDA Approval of
the First Treatment for ALS - Orbis Radio News Special Report.
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Rhone-Poulenc Rorer,
Inc. - New product approved by FDA to treat Lou Gehrig's
Disease - Rilutek
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Drosophila
Meets Lou Gehrig's Disease
An article about using the fruit fly to study the disease.
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The ALS
Newsletter.
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Coenzyme
Q10 Saves Nerve Cells in Mice with ALS
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Myotrophin
Slows Progression Of Lou Gehrig's Disease
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Gene-Reading
Problem Linked To Lou Gehrig's Disease
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Zanaflex® As A
Treatment For Spasticity
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Brain Function
Restored Because of Testes Cells
Brain Function Restored Because of Testes Cells Ny!
13/3/99
SOUTH SAN FRANCISCO, Calif., July 12, 1996 -- A new technology that
involves implanting cells from the testes into the brain may help restore
brain function in victims of Parkinson's disease, stroke, Lou
Gehrig's disease, traumatic brain injury and other brain disorders
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Creatine Supplements Could Help Muscular Disease
Creatine, a food supplement controversial because of its
heavy use by some athletes, may work to help people with diseases such as
muscular dystrophy, researchers said on Wednesday. Patients who took it had
a small but significant improvement in muscle strength and ability to
exercise, Dr. Mark Tarnopolsky of McMaster University Medical Centre in
Hamilton, Ontario, said.
(See
Story from Fox News) (3/12/99)
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AVANIR
(AVNR)
To License Worldwide Rights For Drug To Treat ALS-Related Symptoms
AVANIR Pharmaceuticals (Nasdaq: AVNR), announced today it has
signed a letter of intent, subject to approval of a definitive agreement,
with IriSys Research & Development, LLC to license the worldwide rights
to a new drug to treat a condition associated with Amyotrophic Lateral
Sclerosis (ALS), more commonly known as Lou Gehrig's disease. The new drug
is a patented combination of dextromethorphan and an enzyme
inhibitor, for which the Food and Drug Administration (FDA) has accepted an Investigational
New Drug (IND) application. AVANIR expects to start Phase
II clinical trials in the first half of 1999. Two
other indications to be pursued include treatments of certain types of pain
and chronic intractable cough.
(See
press release) (2/5/99)
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Brain Work
ALS: apparently less settled than we thought. The degenerative
neuromuscular disease amyotrophic lateral sclerosis (ALS), which constrains
the life of world-renowned physicist Stephen Hawking among others, received
a great deal of attention several years ago, when it seemed that the genetic
basis of this fatal disorder was at last becoming clear. But familial ALS
may soon be in the limelight again, as a new study published in Science
(Sept. 18) casts some doubt on the accepted explanation. The new study,
headed by neuroscientist Don Cleveland at the University of California-San
Diego, bred particular strains of mice to manipulate the offspring's
production of an enzyme known as superoxide dismutase, or SOD1. (The
previous thinking was that mutations in the genetic coding for SOD1 caused
some individuals to produce less effective forms of SOD, which were unable
to remove cell-damaging superoxide molecules). Starting from a mutant that
retained little normal function, Cleveland and his colleagues found that
disease onset and progression were not exacerbated by complete removal of
the normal protein, nor were they relieved by increasing it. The scientists
conclude that strategies to treat disease by drugs that increase SOD1
activity are very unlikely to be successful. Further, the evidence calls
into question the initial idea that the toxic effects of the SOD1 mutants
are related to oxidative damage from superoxide.

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